| 1 |
KR 2014/0,142,871 |
Composition containing gamma-mangosteen for preventing or treating degenerative brain disease |
The present invention relates to a composition containing gamma-mangostin as an active ingredient for preventing or treating degenerative brain diseases. The gamma-mangostin of the present invention inhibits oxidative damage in neural cells and apoptosis, has an excellent anti-oxidative effect, and inhibits excitotoxicity in neural cells, activation of A[beta] peptide-induced neurotoxicity and beta-secretase so as to reduce side effects and have excellent effects for preventing nerves and suppressing the synthesis of A[beta] peptide, thereby being able to be useful for preventing or treating degenerative brain diseases including dementia. |
| 2 |
CN 103,432,179 |
Compound mangosteen medicament and preparation process thereof |
The invention discloses a compound mangosteen medicament. The medicament is prepared by mixing the following raw materials in a weight ratio: 10g-60g of mangosteen and 0.5g-5g of L-aspartic acid calcium salt. The invention also provides a preparation process of the compound mangosteen medicament and the preparation process comprises the following steps of: (1) weighing mangosteen, refluxing and extracting with ethanol to prepare fluid extract; (2) preparing the fluid extract into extract powder; (3) granulating the extract powder, and uniformly mixing the granules and the L-aspartic acid calcium salt, and preparing a preparation by a conventional method.; The medicament provided by the invention can be used for treating osteoarthritis, osteoporosis and osteoarthritis complicated with osteoporosis, is safe and effective, and has the characteristics of exact curative effect, small dosage, safe administration, no toxic or side effect and the like, compared with similar medicaments. |
| 3 |
US 2010/0,330,137 |
High bioavailability formulation of mangosteen and manufacturing process thereof |
The present invention relates to a pharmaceutical or dietary composition containing Mangosteen (Garcinia Mangostana pericarp) and being characterized by high bioavailability. A process for the manufacture of this composition is a further object of the present invention. In particular, the present invention relates to a composition containing Mangosteen extract and oligosaccharides in an amount ranging from 5 to 50 w/w % with respect to the Mangosteen extract or a fermented Mangosteen product and to a process for obtaining thereof. |
| 4 |
CN 103,393,576 |
Mangosteen extract and application thereof |
The invention provides a mangosteen extract and application thereof, and the mangosteen extract has good whitening and anti-aging effects, can be used in cosmetics, health food and pharmaceutical fields, and particularly can be used in the cosmetics. |
| 5 |
CN 1,833,665 |
Mangosteen peel extracts, its extraction method and medicine use |
An extract of mangosteen fruit peel as a new Chinese-medicinal material is prepared from the peel of mangosteen fruit through breaking, extracting in alcohol and recovering alcohol. It can be used to treat hyperlipemia, coronary heart disease, angina pectoris and myocardial ischemia. |
| 6 |
WO 2013/036,210 |
Medical face mask coated with mangosteen shell extracts |
This invention is related to the medical face mask coated with mangosteen shell extracts with special and distinguishable feature in that, apart of its capacity to filter-out dust particles, the middle layer which is coated with mangosteen shell extracts has the capacity to protect against tuberculosis and other germs affecting the respiratory system. Furthermore, after use, the medical mask specified in this invention can still kill any germs that are attached on it; thereby, reducing the risk of spreading of diseases through carriers. |
| 7 |
CN 101,525,328 |
Method for extracting alpha-mangostin from mangosteen fruit peel |
The invention relates to a method for extracting alpha-mangostin from a mangosteen fruit peel. The method comprises the following realization steps: (I) extracting the mangosteen fruit peel; (II) concentrating an extracting solution; mixing the extracting solution of every time and concentrating under reduced pressure to obtain a concentrated solution; (III) leaching the solution; (IV) carrying out silica gel column chromatography; (V) carrying out coarse crystallization; and (VI) carrying out recrystallization: adding a primary crystal into an organic solvent with the volume of 1 to 5 times to carry out thermal dissolution; placing the solution after finishing the thermal dissolution, reducing the temperature to a room temperature, carrying out recrystallization, and controlling the crystallization time to between 10 and 20 hours; and filtering and centrifugating a recrystallization liquid, drying the liquid in vacuum to obtain the 98 percent alpha-mangostin. The method has the advantages of simple process and short operation time. |
| 8 |
CN 103,211,850 |
Method for extracting flavone from mangosteen skin |
The invention provides a method for extracting flavone from mangosteen skin. The method provided by the invention comprises the following main processes: 1, cleaning; 2, drying; 3, smashing; 4, charging; 5, carrying out ultrasonic wave extracting; 6, filtering; and 7 carrying out purification concentration. The flavone extracted by the invention is a flavonoid compound and a natural activity product widely distributed in plants, is low in molecular weight and is a plant polyphenol metabolic product; the flavone extracted by the invention is a compound of a 2-phenyl chromone structure; the flavone extracted by the invention has an extensively biological activity effect and can be frequently used for resisting oxidation, resisting ageing, eliminating free radicals, reducing blood pressure, reducing blood fat, resisting bacteria, diminishing inflammation and improving immunity; the flavone can also be widely applied to cosmetics; and use of the flavone is extensive, and the flavone is also high in price, so that great significance is produced while the flavone is extracted from the mangosteen skin. |
| 9 |
CN 104,892,56 |
Method for extracting high-content alpha-mangostin from mangosteen skin |
The invention discloses a method for extracting high-content alpha-mangostin from mangosteen skin. The method comprises the following steps: (1) extracting: crushing mangosteen skin raw materials, placing the crushed mangosteen skin raw materials into an extracting device, adding an acid alcohol solvent in amount which is 4 to 5 times the weight of the mangosteen skin raw materials, placing the solution into water bath at the temperature of 85-95 DEG C, extracting for 2 to 3 times and for 1.5 to 2 hours at each time, combining the extracting liquids and filtering to obtain the filtered extracting liquid; and (2) performing chromatography: allowing the filtered liquid to pass through a neutral alumina chromatographic column, performing gradient elution, collecting the eluent, concentrating the eluent under reduced pressure until no alcohol taste exists, standing the eluent at the temperature of 4 DEG C for more than or equal to 4 hours until crystallization, centrifuging, and taking the precipitate to obtain the finished product. The method has the advantages of few steps, low time consumption, little reagent dosage and low cost, and is simple to operate and easy to control. By the method, the alpha-mangostin with the highest content of more than or equal to 99.0% can be obtained. The method is suitable for industrialized production. |
| 10 |
CN 101,816,687 |
Method for extracting mangosteen pericarp anthocyanin and application thereof in preparing anti-inflammatory drugs |
The invention belongs to the field of natural medicinal chemistry, in particular to separation and extraction of natural anti-inflammatory drug molecules and an application thereof. The method comprises the following steps of extracting by acidic ethanol, decompressing and concentrating, adding water for dissolving, loading a sample in XAD-7 macroporous resin, eluting, collecting and concentrating, freeze-drying to extract the mangosteen pericarp anthocyanin. Experimental results show that mouse peritoneal fluid neutrophil exudation can be effectively inhibited after the mangosteen pericarp anthocyanin is injected into caudal vein of the mouse, the inhibition ratios are respectively 34%, 77% and 94% while the dosages are respectively 0.01, 0.1 and 1mg/ml.; A laminar experiment using an in-vitro simulated capillary proves that the adhesion inhibition ratios of the mangosteen pericarp anthocyanin on neutrophil are respectively 45%, 71% and 89% while the dosages are respectively 0.01, 0.1 and 1mg/ml. Therefore, the anti-inflammatory activity of the mangosteen pericarp anthocyanin is proved, and the mangosteen pericarp anthocyanin as a novel anti-inflammatory drug has good application prospect. |
| 11 |
CN 105,130,944 |
Method for extracting procyanidine from mangosteen shells |
The invention relates to a method for extracting procyanidine from mangosteen shells. According t to the method, mangosteen shells serve as raw materials, and procyanidine is extracted through combination of an enzymic preparation and a solvent. The preparing method comprises the following steps of preparing materials, preparing a buffering solution, preparing an enzyme solution, casting the materials, carrying out enzymolysis, carrying out extraction and forming a finished product. The obtained procyanidine product can be applied to natural pigment food additives, medicine healthcare products with the anti-oxidation effect, cosmetics and other industries. |
| 12 |
CN 104,435,019 |
Novel pharmaceutical application of mangosteen shell extract |
The invention discloses a novel pharmaceutical application of a mangosteen shell extract. The mangosteen shell extract is applied to preparation of the following products: (1) a product for preventing and/or treating the Parkinson disease; (2) a product for preventing and/or treating the degenerative change of dopaminergic neuron dendrites of a patient suffering from the Parkinson disease; (3) an oxidative-stress-resistant product; and (4) a product for preventing and/or treating oxidative stress of the Parkinson disease. Pharmacodynamic experiments prove that the mangosteen shell extract can be used for recovering (parts of) dopaminergic neuron dendrites of a nematode model suffering from the a30p Parkinson disease, and can also be used for inhibiting the level of reactive oxygen in the nematode model suffering from the Parkinson disease induced by rotenone. Furthermore, the mangosteen shell extract is proved to have relatively good Parkinson disease resistance and oxidative stress resistance. |
